About Tweet

We are a multidisciplinary junior group that answers clinical questions related to deep brain stimulation and the pathophysiology of movement disorders through computer visualisation and modelling.

Brainscan (CT) of a patient with implanted electrodes. Target structures are overlayed in color.

What is deep brain stimulation?

Deep brain stimulation is a neurological therapy that involves the insertion deep inside the brain of one or more small electrodes giving small electrical pulses. When targeted correctly, DBS has the potential to vastly reduce disease symptoms and improve the quality of life. Comparable to a cardiac pacemaker the device will be chronically implanted.

For essential tremor, Parkinson’s disease and dystonia, DBS is an established therapy that has existed for over two decades. Nevertheless, most of the mechanisms of the therapy are superficially understood, and patients show great outcome variability.


Cables run down through the neck to the battery that is implanted near the clavicle.

What do we do?

We aim to provide the best possible therapy for the patients who we see in the university hospital Uniklinikum Würzburg in Germany. As each patient is different, every treatment teaches us something new about the (distorted) mechanisms of the brain.

In our lab, we focus on the analysis of images together with surgical and stimulation data. Our main goal is to refine the existing pathophysiological models and subsequently translate the scientific models to clinical practice in order to improve daily DBS patient care.







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For more insight in the mysteries of the brain we need better images of what happens inside our skull. We use advanced scanning techniques and analysis tools to make 3-dimensional images that will tell stories that could have never been told before.